Mesalamine is a medication known as an anti-inflammatory agent that is prescribed to treat a condition known as ulcerative colitis where there is sores and swelling in the rectum lining or the colon lining. Additionally mesalamine is also used in order to treat the various symptoms of ulcerative colitis.
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How should it be used?
Mesaline cost is reasonable and affordable and it works by delayed release, releasing the medication when needed by the intestine. Also, there are mesalamine tablets with controlled release and extended release. The medicine has to be taken by the mouth with water, and your doctor will inform you about the frequency of medication, which depends on your condition and the extent of control gained over the symptoms. You should take this medicine exactly as directed and do not take less or more of it.
Mechanism of action of mesalamine
Mesalamine is an anti-inflammatory agent, stopping the body from producing substances that cause inflammation. Specifically, it blocks activities of lipoxygenase and cycloxigenase. This inhibits the production of prostaglandins, thereby reducing the inflammation in the rectum or the colon.
Side effects of Mealamine
Some of the common side effects of this medication are:
- Irritation of the throat
- Inflammation in the tissue that lines the sinuses
Some effects are serious, and you should consult your doctor if you have;
- Pain in the chest
- Tarry or black stools
- Shortness of breath
- Vomit that has blood
- Vomiting substances that look like grounds of coffee
- Swelling at any part of the body.
How long can you stay on this medication?
Adults are generally prescribed 1600mg of mesalamine given 3 times a day for a period of 6 weeks. For children, the dosage and the frequency have to be determined by the presiding doctor.
Is Mesalamine safe for the long term?
Studies show and demonstrate the fact that mesalamine is tolerated well in the case of long term remission of patients who have ulcerative colitis. Also there is a low risk of recurrence of ulcerative colitis with mesalamine. Often, patients require life –long maintenance to keep remission at check, so mesalamine has to be assessed for long term safety.
Is mesalamine effective?
In the mild and moderate cases of ulcerative colitis, mesalamine has response rate of 40%-70%. Associated remission rates are at 15%-20%. For mild or moderate cases, the optimum dosage is 4g/day and that for maintenance therapy is 2.4g/day.
Does mesalamine need to be tapered?
Mesalamine needs to be tapered off gradually after successful treatment of ulcerative colitis and abrupt discontinuation should be avoided.
Special precautions while taking Mesacalamine
- You may be allergic to mesacalamine cost or any other ingredient of the medication, so you should let your doctor know of this.
- Give the doctor an exhaustive list of the current medications that you take, including both prescription and non-prescription meds, nutritional supplements and any other vitamins.
- Tell the doctor if you ever suffered from myocarditis, pericarditis, kidney or liver disease. Also let the doctor know if you had gastrointestinal obstruction in the past.
- The doctor need to know if you are pregnant or plan to in the future, as well as if you are breastfeeding or not.
- Meacalamine can rarely cause a serious reaction whose symptoms are the same as ulcerative colitis. So get in touch with your doctor if you experience cramping or stomach pain, headache, fever, rash or weakness.